Background and Objectives: It is known that various inflammatory mediators released from the eosinophils and mast cells play important roles in the pathogenesis of nasal polyp. Among those mediators, the arachidonic acid has particular
importance
as a precursor of other mediators. By assaying the tissue concentration of the 6-keto-PGF1α, leukotrienes (LTs), and hydroxyeicosatetraenoic acids(HETE) in the nasal polyp, we aimed to investigate the role of arachidonic acid
metabolite
in
the pathogenesis of antrochoanal polyp and nasal polyp associated with chronic paranasal sinusitis. Materials and Methods: Three turbinate tissues taken during the septoplastry were served as the control. The experimental group consisted
of
3
antrochoanal polyps and 7 inflammatory polyps. The tissue level of the 6-keto-PGF1α, LTC4, LTD4, LTE4<,/sub>, 15-HETE, and 12-HETE were measured using high performance liquid chromatography. Results:
The
level of 6-keto-PGF1α, LTC4, 15-HETE, 12-HETE were significantly lower in antrochoanal polyp than in the control turbinate. In the inflammatory polyp, the levels of 6-keto-PGF1α and LTC4 were lower
than
the
control. However, in the inflammatory polyp, LTD4 and LTE4 were detectable, which were not detected in the control turbinate and antrochoanal polyp. Conclusion: The results of this study indicate that the decreased
arachidonic acid metabolism may underlie the pathogenesis of the antrochoanal polyp. However, in the pathogenesis of inflammatory polyp, the increased production of LTD4 and LTE4 may have an important role.
|